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Wu, F.* ; Cheng, Y.* ; Wu, L.* ; Zhang, W.* ; Zheng, W.* ; Wang, Q. ; Cao, H.* ; Pan, X.* ; Tang, W.*

Emerging landscapes of tumor immunity and metabolism.

Front. Oncol. 10:575037 (2020)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
The metabolic reprogramming of cancer tissue has higher metabolic activity than surrounding tissues. At the same time, the local infiltration of immunosuppressive cells is also significantly increased, resulting in a significant decrease in tumor immunity. During the progression of cancer cells, immunosuppressive tumor microenvironment is formed around the tumor due to their metabolic reprogramming. In addition, it is the changes in metabolic patterns that make tumor cells resistant to certain drugs, impeding cancer treatment. This article reviews the mechanisms of immune escape caused by metabolic reprogramming, and aims to provide new ideas for clinical tumor immunotherapy combined with metabolic intervention for tumor treatment.
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Publication type Article: Journal article
Document type Review
Keywords Cancer ; Metabolism ; Immunity ; Reprogram ; Drug Resistance; T-cell Metabolism; Molecular Pathways; Antitumor Immunity; Glutamine Uptake; Cancer; Memory; Acid; Resistance; Kinase; Expression
ISSN (print) / ISBN 2234-943X
e-ISSN 2234-943X
Quellenangaben Volume: 10, Issue: , Pages: , Article Number: 575037 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Reviewing status Peer reviewed
Grants Jiangsu Natural Science Foundation