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Leger, S.* ; Zwanenburg, A.* ; Leger, K.* ; Lohaus, F.* ; Linge, A.* ; Schreiber, A.* ; Kalinauskaite, G.* ; Tinhofer, I.* ; Guberina, N.* ; Guberina, M.* ; Balermpas, P.* ; Von der Grün, J.* ; Ganswindt, U. ; Belka, C. ; Peeken, J.C. ; Combs, S.E. ; Boeke, S.* ; Zips, D.* ; Richter, C.* ; Krause, M.* ; Baumann, M.* ; Troost, E.G.C.* ; Löck, S.*

Comprehensive analysis of tumour sub-volumes for radiomic risk modelling in locally advanced HNSCC.

Cancers 12:3047 (2020)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Simple Summary: Radiomic risk models are usually based on imaging features, which are extracted from the entire gross tumour volume (GTVentire). This approach does not explicitly consider the complex biological structure of the tumours. Therefore, in this retrospective study, we investigated the prognostic value of radiomic analyses based on different tumour sub-volumes using computed tomography imaging of patients with locally advanced head and neck squamous cell carcinoma who were treated with primary radio-chemotherapy. The GTVentire was cropped by different margins to define the rim and corresponding core sub-volumes of the tumour. Furthermore, the best performing tumour rim sub-volume was extended into surrounding tissue with different margins. As a result, the models based on the 5 mm tumour rim and on the 3 mm extended rim sub-volume showed an improved performance compared to models based on the corresponding tumour core. This indicates that the consideration of tumour sub-volumes may help to improve radiomic risk models.Imaging features for radiomic analyses are commonly calculated from the entire gross tumour volume (GTVentire). However, tumours are biologically complex and the consideration of different tumour regions in radiomic models may lead to an improved outcome prediction. Therefore, we investigated the prognostic value of radiomic analyses based on different tumour sub-volumes using computed tomography imaging of patients with locally advanced head and neck squamous cell carcinoma. The GTVentire was cropped by different margins to define the rim and the corresponding core sub-volumes of the tumour. Subsequently, the best performing tumour rim sub-volume was extended into surrounding tissue with different margins. Radiomic risk models were developed and validated using a retrospective cohort consisting of 291 patients in one of the six Partner Sites of the German Cancer Consortium Radiation Oncology Group treated between 2005 and 2013. The validation concordance index (C-index) averaged over all applied learning algorithms and feature selection methods using the GTVentire achieved a moderate prognostic performance for loco-regional tumour control (C-index: 0.61 +/- 0.04 (mean +/- std)). The models based on the 5 mm tumour rim and on the 3 mm extended rim sub-volume showed higher median performances (C-index: 0.65 +/- 0.02 and 0.64 +/- 0.05, respectively), while models based on the corresponding tumour core volumes performed less (C-index: 0.59 +/- 0.01). The difference in C-index between the 5 mm tumour rim and the corresponding core volume showed a statistical trend (p = 0.10). After additional prospective validation, the consideration of tumour sub-volumes may be a promising way to improve prognostic radiomic risk models.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Radiomic ; Image-based Risk Modelling ; Machine Learning ; Personalised Therapy ; Radiation Oncology; Primary Radiochemotherapy; Radiation Oncology; Prospective Trial; Hypoxia; Cancer; Head; Heterogeneity; Delineation; Survival
ISSN (print) / ISBN 2072-6694
Journal Cancers
Quellenangaben Volume: 12, Issue: 10, Pages: , Article Number: 3047 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) CCG Personalized Radiotherapy in Head and Neck Cancer (KKG-KRT)
Institute of Radiation Medicine (IRM)
Grants Federal Ministry of Education and Research