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Alkotob, S.S.* ; Cannedy, C.* ; Zeiser, K. ; Movassagh, H.* ; Paudel, B.* ; Prunicki, M.* ; Sampath, V.* ; Schikowski, T.* ; Smith, E.* ; Zhao, Q.* ; Traidl-Hoffmann, C. ; Nadeau, K.C.*

Advances and novel developments in environmental influences on the development of atopic diseases.

Allergy 75, 3077-3086 (2020)
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Free by publisher: Publ. Version/Full Text online available 12/2022
Although genetic factors play a role in the etiology of atopic disease, the rapid increases in the prevalence of these diseases over the last few decades suggest that environmental, rather than genetic factors are the driving force behind the increasing prevalence. In modern societies, there is increased time spent indoors, use of antibiotics, and consumption of processed foods and decreased contact with farm animals and pets, which limit exposure to environmental allergens, infectious parasitic worms, and microbes. The lack of exposure to these factors is thought to prevent proper education and training of the immune system. Increased industrialization and urbanization have brought about increases in organic and inorganic pollutants. In addition, Caesarian birth, birth order, increased use of soaps and detergents, tobacco smoke exposure and psychosomatic factors are other factors that have been associated with increased rate of allergic diseases. Here, we review current knowledge on the environmental factors that have been shown to affect the development of allergic diseases and the recent developments in the field.
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Publication type Article: Journal article
Document type Review
Keywords Allergy ; Atopic Disease ; Environment ; Exposome ; Pollution; Air-pollution; Allergic Sensitization; Pediatric Asthma; Cesarean-section; Smoke Exposure; Climate-change; Food Allergy; Serum Ige; Dermatitis; Stress
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 75, Issue: 12, Pages: 3077-3086 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)
Grants Sean N. Parker Center for Allergy and Asthma Research at Stanford University