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Hannemann, A.* ; Meisinger, C. ; Bidlingmaier, M.* ; Döring, A. ; Thorand, B. ; Heier, M. ; Belcredi, P. ; Ladwig, K.-H. ; Wallaschofski, H.* ; Friedrich, N.* ; Schipf, S.* ; Lüdemann, J.* ; Rettig, R.* ; Peters, J.* ; Völzke, H.* ; Seissler, J.* ; Beuschlein, F.* ; Nauck, M.* ; Reincke, M.*

Association of plasma aldosterone with the metabolic syndrome in two German populations.

Eur. J. Endocrinol. 164, 751-768 (2011)
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The aim of this study was to analyze the potential association of the plasma aldosterone concentration (PAC) with the metabolic syndrome (MetS) and its components in two German population-based studies. We selected 2830 and 2901 participants (31-80 years) from the follow-ups of the Study of Health in Pomerania (SHIP)-1 and the Cooperative Health Research in the Region of Augsburg (KORA) F4 respectively. MetS was defined as the presence of at least three out of the following five criteria: waist circumference ≥94 cm (men (m)) and ≥80 cm (women (w)); high-density lipoprotein (HDL) cholesterol <1.0 mmol/l (m) and <1.3 mmol/l (w); blood pressure ≥130/85 mmHg or antihypertensive treatment; non-fasting glucose (SHIP-1) ≥8 mmol/l, fasting glucose (KORA F4) ≥5.55 mmol/l or antidiabetic treatment; non-fasting triglycerides (SHIP-1) ≥2.3 mmol/l, fasting triglycerides (KORA F4) ≥1.7 mmol/l, or lipid-lowering treatment. We calculated logistic regression models by comparing the highest study- and sex-specific PAC quintiles versus all lower quintiles. MetS was common with 48.1% (m) and 34.8% (w) in SHIP-1 and 42.7% (m) and 27.5% (w) in KORA F4. Our logistic regression models revealed associations of PAC with MetS, elevated triglycerides, and decreased HDL cholesterol in SHIP-1 and KORA F4. Our findings add to the increasing evidence supporting a relation between aldosterone and MetS and suggest that aldosterone may be involved in the pathophysiology of MetS and lipid metabolism disorders.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter mineralocorticoid receptor; resistant hypertension; insulin-resistance; prevalence; health; obesity; management; diagnosis; renin; serum
ISSN (print) / ISBN 0804-4643
e-ISSN 1479-683X
Quellenangaben Band: 164, Heft: 5, Seiten: 751-768 Artikelnummer: , Supplement: ,
Verlag BioScientifica
Verlagsort Oslo, Norway
Begutachtungsstatus Peer reviewed