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Hannemann, A.* ; Meisinger, C. ; Bidlingmaier, M.* ; Döring, A. ; Thorand, B. ; Heier, M. ; Belcredi, P. ; Ladwig, K.-H. ; Wallaschofski, H.* ; Friedrich, N.* ; Schipf, S.* ; Lüdemann, J.* ; Rettig, R.* ; Peters, J.* ; Völzke, H.* ; Seissler, J.* ; Beuschlein, F.* ; Nauck, M.* ; Reincke, M.*

Association of plasma aldosterone with the metabolic syndrome in two German populations.

Eur. J. Endocrinol. 164, 751-768 (2011)
Open Access Green as soon as Postprint is submitted to ZB.
The aim of this study was to analyze the potential association of the plasma aldosterone concentration (PAC) with the metabolic syndrome (MetS) and its components in two German population-based studies. We selected 2830 and 2901 participants (31-80 years) from the follow-ups of the Study of Health in Pomerania (SHIP)-1 and the Cooperative Health Research in the Region of Augsburg (KORA) F4 respectively. MetS was defined as the presence of at least three out of the following five criteria: waist circumference ≥94 cm (men (m)) and ≥80 cm (women (w)); high-density lipoprotein (HDL) cholesterol <1.0 mmol/l (m) and <1.3 mmol/l (w); blood pressure ≥130/85 mmHg or antihypertensive treatment; non-fasting glucose (SHIP-1) ≥8 mmol/l, fasting glucose (KORA F4) ≥5.55 mmol/l or antidiabetic treatment; non-fasting triglycerides (SHIP-1) ≥2.3 mmol/l, fasting triglycerides (KORA F4) ≥1.7 mmol/l, or lipid-lowering treatment. We calculated logistic regression models by comparing the highest study- and sex-specific PAC quintiles versus all lower quintiles. MetS was common with 48.1% (m) and 34.8% (w) in SHIP-1 and 42.7% (m) and 27.5% (w) in KORA F4. Our logistic regression models revealed associations of PAC with MetS, elevated triglycerides, and decreased HDL cholesterol in SHIP-1 and KORA F4. Our findings add to the increasing evidence supporting a relation between aldosterone and MetS and suggest that aldosterone may be involved in the pathophysiology of MetS and lipid metabolism disorders.
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Publication type Article: Journal article
Document type Scientific Article
Keywords mineralocorticoid receptor; resistant hypertension; insulin-resistance; prevalence; health; obesity; management; diagnosis; renin; serum
ISSN (print) / ISBN 0804-4643
e-ISSN 1479-683X
Quellenangaben Volume: 164, Issue: 5, Pages: 751-768 Article Number: , Supplement: ,
Publisher BioScientifica
Publishing Place Oslo, Norway
Reviewing status Peer reviewed