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Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin.

Nat. Commun. 11:5653 (2020)
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Open Access Gold
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Scars are more severe when the subcutaneous fascia beneath the dermis is injured upon surgical or traumatic wounding. Here, we present a detailed analysis of fascia cell mobilisation by using deep tissue intravital live imaging of acute surgical wounds, fibroblast lineage-specific transgenic mice, and skin-fascia explants (scar-like tissue in a dish – SCAD). We observe that injury triggers a swarming-like collective cell migration of fascia fibroblasts that progressively contracts the skin and form scars. Swarming is exclusive to fascia fibroblasts, and requires the upregulation of N-cadherin. Both swarming and N-cadherin expression are absent from fibroblasts in the upper skin layers and the oral mucosa, tissues that repair wounds with minimal scar. Impeding N-cadherin binding inhibits swarming and skin contraction, and leads to reduced scarring in SCADs and in animals. Fibroblast swarming and N-cadherin thus provide therapeutic avenues to curtail fascia mobilisation and pathological fibrotic responses across a range of medical settings.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Pulmonary-fibrosis; Tgf-beta; Regeneration
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Quellenangaben Volume: 11, Issue: 1, Pages: , Article Number: 5653 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Grants China Scholarship Council (CSC)
Deutscher Akademischer Austauschdienst (DAAD)
Consejo Nacional de Ciencia y Tecnologia (CONACYT)
European Research Council Consolidator Grant
German Research Foundation
Human Frontier Science Program Career Development Award