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Merid, S.K.* ; Bustamante, M.* ; Standl, M. ; Sunyer, J.* ; Heinrich, J.* ; Lemonnier, N.* ; Aguilar, D.* ; Antó, J.M.* ; Bousquet, J.* ; Santa-Marina, L.* ; Lertxundi, A.* ; Bergström, A.* ; Kull, I.* ; Wheelock, Å.M.* ; Koppelman, G.H.* ; Melén, E.* ; Gruzieva, O.*

Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure.

Environ. Int. 146:106248 (2021)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-wide association studies of 656 children and adolescents from three European cohorts participating in the MeDALL Consortium, we found two differentially expressed transcript clusters (FDR p < 0.05) associated with exposure to particulate matter < 2.5 µm in diameter (PM2.5) at birth, one of them mapping to the MIR1296 gene. Further, by integrating gene expression with DNA methylation using Functional Epigenetic Modules algorithms, we identified 9 and 6 modules in relation to PM2.5 exposure at birth and at current address, respectively (including NR1I2, MAPK6, TAF8 and SCARA3). In conclusion, PM2.5 exposure at birth was linked to differential gene expression in children and adolescents. Importantly, we identified several significant interactome hotspots of gene modules of relevance for complex diseases in relation to PM2.5 exposure.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Air Pollution ; Children ; Dna Methylation ; Gene Expression ; Integration; Air-pollution Exposure; Childhood Asthma; Microrna-1296; Proliferation; Metaanalysis; Adolescence; Association; Invasion; Profile; Cohort
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Quellenangaben Band: 146, Heft: , Seiten: , Artikelnummer: 106248 Supplement: ,
Verlag Elsevier
Verlagsort The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Begutachtungsstatus Peer reviewed
Förderungen ANR-15-IDEX-02
company Mead Johnson
7th Framework Program: MeDALL project
Commission of the European Communities
Federal Ministry for Environment (IUF Dusseldorf)
Swedish Research Council for Health, Working life and Welfare
Cancer and Allergy Foundation
Swedish Asthma and Allergy Research Foundation
Swedish Environment Protection Agency
Swedish Research Council Formas
Strategic Research Programme (SFO) in Epidemiology at Karolinska Institutet
Region Stockholm
Swedish Heart-Lung Foundation
Swedish Research Council
European Research Council
company Nestle
Commission of the European Community
municipality of the study area (Beasain)
municipality of the study area (Azpeitia)
municipality of the study area (Azkoitia)
municipality of the study area (Legazpi)
municipality of the study area (Urretxu)
municipality of the study area (Zumarraga)
Provincial Government of Gipuzkoa
Department of Health of the Basque Government
Generalitat de Catalunya
Instituto de Salud Carlos III (FEDER funds)
European Community's Seventh Framework Program