Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-wide association studies of 656 children and adolescents from three European cohorts participating in the MeDALL Consortium, we found two differentially expressed transcript clusters (FDR p < 0.05) associated with exposure to particulate matter < 2.5 µm in diameter (PM2.5) at birth, one of them mapping to the MIR1296 gene. Further, by integrating gene expression with DNA methylation using Functional Epigenetic Modules algorithms, we identified 9 and 6 modules in relation to PM2.5 exposure at birth and at current address, respectively (including NR1I2, MAPK6, TAF8 and SCARA3). In conclusion, PM2.5 exposure at birth was linked to differential gene expression in children and adolescents. Importantly, we identified several significant interactome hotspots of gene modules of relevance for complex diseases in relation to PM2.5 exposure.
FörderungenANR-15-IDEX-02 company Mead Johnson 7th Framework Program: MeDALL project Commission of the European Communities Federal Ministry for Environment (IUF Dusseldorf) Swedish Research Council for Health, Working life and Welfare Cancer and Allergy Foundation Swedish Asthma and Allergy Research Foundation Swedish Environment Protection Agency Swedish Research Council Formas Strategic Research Programme (SFO) in Epidemiology at Karolinska Institutet Region Stockholm Swedish Heart-Lung Foundation Swedish Research Council European Research Council company Nestle Commission of the European Community municipality of the study area (Beasain) municipality of the study area (Azpeitia) municipality of the study area (Azkoitia) municipality of the study area (Legazpi) municipality of the study area (Urretxu) municipality of the study area (Zumarraga) Provincial Government of Gipuzkoa Department of Health of the Basque Government Generalitat de Catalunya Instituto de Salud Carlos III (FEDER funds) European Community's Seventh Framework Program