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Langenau, J.* ; Oluwagbemigun, K.* ; Brachem, C.* ; Lieb, W.* ; di Giuseppe, R.* ; Artati, A. ; Kastenmüller, G. ; Weinhold, L.* ; Schmid, M.* ; Nöthlings, U.*

Blood metabolomic profiling confirms and identifies biomarkers of food intake.

Metabolites 10:468 (2020)
Verlagsversion Forschungsdaten DOI
Open Access Gold
Creative Commons Lizenzvertrag
Metabolomics can be a tool to identify dietary biomarkers. However, reported food-metabolite associations have been inconsistent, and there is a need to explore further associations. Our aims were to confirm previously reported food-metabolite associations and to identify novel food-metabolite associations. We conducted a cross-sectional analysis of data from 849 participants (57% men) of the PopGen cohort. Dietary intake was obtained using FFQ and serum metabolites were profiled by an untargeted metabolomics approach. We conducted a systematic literature search to identify previously reported food-metabolite associations and analyzed these associations using linear regression. To identify potential novel food-metabolite associations, datasets were split into training and test datasets and linear regression models were fitted to the training datasets. Significant food-metabolite associations were evaluated in the test datasets. Models were adjusted for covariates. In the literature, we identified 82 food-metabolite associations. Of these, 44 associations were testable in our data and confirmed associations of coffee with 12 metabolites, of fish with five, of chocolate with two, of alcohol with four, and of butter, poultry and wine with one metabolite each. We did not identify novel food-metabolite associations; however, some associations were sex-specific. Potential use of some metabolites as biomarkers should consider sex differences in metabolism.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Biomarkers ; Dietary Assessment Methods ; Dietary Intake ; Metabolites ; Untargeted Metabolomics; Dietary Patterns; Serum; Association; Consumption; Frequency; Risk
ISSN (print) / ISBN 2218-1989
e-ISSN 2218-1989
Zeitschrift Metabolites
Quellenangaben Band: 10, Heft: 11, Seiten: , Artikelnummer: 468 Supplement: ,
Verlag MDPI
Verlagsort St Alban-anlage 66, Ch-4052 Basel, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Computational Biology (ICB)
Förderungen BMBF project
Diet-Body-Brain (DietBB) the Competence Cluster in Nutrition Research - Federal Ministry of Education and Research (BMBF)