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The metabolic underpinnings of ferroptosis.

Cell Metab. 32, 920-937 (2020)
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Free by publisher: Publ. Version/Full Text online available 12/2021
Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis. Ferroptosis is unique among the different cell death modalities, as it has been mostly linked to pathophysiological conditions and because several metabolic pathways, such as (seleno)thiol metabolism, fatty acid metabolism, iron handling, mevalonate pathway, and mitochondrial respiration, directly impinge on the cells’ sensitivity toward lipid peroxidation and ferroptosis. Additionally, key cellular redox systems, such as selenium-dependent glutathione peroxidase 4 and the NAD(P)H/ferroptosis suppressor protein-1/ubiquinone axis, are at play that constantly surveil and neutralize oxidative damage to cellular membranes. Since this form of cell death emerges to be the root cause of a number of diseases and since it offers various pharmacologically tractable nodes for therapeutic intervention, there has been overwhelming interest in the last few years aiming for a better molecular understanding of the ferroptotic death process.
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Publication type Article: Journal article
Document type Review
Keywords Ferroptosis ; Fsp1 ; Gpx4 ; Lipid Peroxidation ; Redox Metabolism; Glutathione-peroxidase 4; Erastin-induced Ferroptosis; Cisplatin-resistant Head; Neck-cancer Cells; Lipid-peroxidation; Oxidative Stress; System X(c)(-); Vitamin-e; Cystine/glutamate Transporter; Transsulfuration Pathway
ISSN (print) / ISBN 1550-4131
e-ISSN 1932-7420
Journal Cell Metabolism
Quellenangaben Volume: 32, Issue: 6, Pages: 920-937 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Grants Bavarian Ministry of Economic Affairs, Regional Development and Energy (StMWi)
European Research Council (ERC) under the European Union
Else Kroner-Fresenius-Stiftung
Ministry of Science and Higher Education of The Russian Federation
Helmholtz Validation Fund
German Federal Ministry of Education and Research (BMBF) VIP+ program NEUROPROTEKT
Deutsche Forschungsgemeinschaft (DFG)