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Kidney-derived PCSK9-a new driver of hyperlipidemia in nephrotic syndrome?

Kidney Int. 98, 1393-1395 (2020)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Increased plasma concentrations of proprotein convertase subtilisin/kexin type 9 or PCSK9, which reduces hepatic uptake of low-density lipoprotein by downregulation of the low-density lipoprotein receptor, have been reported in nephrotic patients and might contribute to hyperlipidemia in nephrotic syndrome. The results of the study by Molina-Jijon et al. found that renal PCSK9 expression was upregulated in the collecting duct of nephrotic patients and animals, suggesting that the kidney might be a major source for plasma PCSK9 in nephrotic syndrome.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Sonstiges: Meinungsartikel
Schlagwörter Subtilisin/kexin Type 9; Metabolism
ISSN (print) / ISBN 0085-2538
e-ISSN 1523-1755
Zeitschrift Kidney International
Quellenangaben Band: 98, Heft: 6, Seiten: 1393-1395 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Begutachtungsstatus Peer reviewed