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Stylogiannis, A. ; Riobo, L. ; Prade, L. ; Glasl, S. ; Klein, S.* ; Lucidi, G.* ; Fuchs, M.* ; Saur, D.* ; Ntziachristos, V.

Low-cost single-point optoacoustic sensor for spectroscopic measurement of local vascular oxygenation.

Opt. Lett. 45, 6579-6582 (2020)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Optical sensors developed for the assessment of oxygen in tissue microvasculature, such as those based on near-infrared spectroscopy, are limited in application by light scattering. Optoacoustic methods are insensitive to light scattering, and therefore, they can provide higher specificity and accuracy when quantifying local vascular oxygenation. However, currently, to the best of our knowledge, there is no low-cost, single point, optoacoustic sensor for the dedicated measurement of oxygen saturation in tissue microvasculature. This work introduces a spectroscopic optoacoustic sensor (SPOAS) for the non-invasive measurement of local vascular oxygenation in real time. SPOAS employs continuous wave laser diodes and measures at a single point, which makes it low-cost and portable. The SPOAS performance was benchmarked using blood phantoms, and it showed excellent linear correlation (R2 = 0.98) with a blood gas analyzer. Subsequent measurements of local vascular oxygenation in living mice during an oxygen stress test correlated well with simultaneous readings from a reference instrument.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Blood Oxygenation; Tomography; Principles; Saturation
ISSN (print) / ISBN 0146-9592
e-ISSN 1539-4794
Zeitschrift Optics Letters
Quellenangaben Band: 45, Heft: 24, Seiten: 6579-6582 Artikelnummer: , Supplement: ,
Verlag Optical Society of America (OSA)
Verlagsort 2010 Massachusetts Ave Nw, Washington, Dc 20036 Usa
Begutachtungsstatus Peer reviewed
Förderungen Bundesministerium für Bildung und Forschung
H2020 European Union
H2020 European Research Council