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Schuh, L. ; Loos, C. ; Pokrovsky, D.* ; Imhof, A.* ; Rupp, R.A.W.* ; Marr, C.

H4K20 methylation is differently regulated by dilution and demethylation in proliferating and cell-cycle-arrested xenopus embryos.

Cell Syst. 11, 653-662.e8 (2020)
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Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
H4K20me kinetics in normal and cell-cycle-arrested Xenopus embryos. This quantitative model invokes specific methylation and unspecific demethylation and correctly predicts cell-cycle durations and cell-cycle dependencies. Active demethylation is not required to explain H4K20me kinetics of cycling cells, suggesting that overall H4K20me dilution through DNA replication is dominant. So only once cells stop cycling during embryogenesis, active H4K20 demethylation may contribute to shape histone methylation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Computational Modeling ; Demethylation ; Development ; Epigenetics ; Histone Post-translational Modifications ; Methylation Kinetics ; Ordinary Differential Equations ; Xenopus Laevis; Histone H4; Parameter-estimation; Lysine-20; Chromatin; Methyltransferase; Monomethylation; Trimethylation; Purification; Specificity; Transition
ISSN (print) / ISBN 2405-4712
e-ISSN 2405-4720
Journal Cell Systems
Quellenangaben Volume: 11, Issue: 6, Pages: 653-662.e8 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Maryland Heights, MO
Grants Technical University of Munich's Department of Mathematics
European Research Council (ERC)
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
BMBF project TIDY