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Diem, O.C. ; Schäffner, M. ; Frohnmeyer, M.* ; Hemby, S.E.* ; Frank, O.* ; Seifarth, W. ; Leib-Mösch, C.

Influence of antipsychotic medication on endogenous retrovirus (ERV) expression in brain cells.

In: Proceedings (Centennial Retrovirus Meeting, 29th April - 4th May 2010, Prague, Czech Republic). Bologna: Medimond, 2010. 39-43
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The detection of endogenous retrovirus-derived transcripts in brain samples of patients with schizophrenia and related disorders suggests a possible role of such elements in neuropsychiatric diseases. However, most patients receive antipsychotic drugs that may influence the expression activity of human endogenous retroviruses (HERVs). Monitoring HERV transcription with a retrovirus pol-based DNA chip in a human glioblastoma cell line treated with valproic acid revealed a dose-dependent up-regulation of HERV activity, whereas other antipsychotic drugs such as haloperidol and clozapine showed little or no effect. In brain tissue of rhesus monkeys treated with haloperidol or clozapine no increase of endogenous retrovirus (ERV) transcript levels could be detected.
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Publikationstyp Artikel: Konferenzbeitrag
ISBN 978-88-7587-586-2
Konferenztitel Centennial Retrovirus Meeting
Konferzenzdatum 29th April - 4th May 2010
Konferenzort Prague, Czech Republic
Konferenzband Proceedings
Quellenangaben Band: , Heft: , Seiten: 39-43 Artikelnummer: , Supplement: ,
Verlag Medimond
Verlagsort Bologna