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The emerging role of miRNAs for the radiation treatment of pancreatic cancer.

Cancers 12:3703 (2020)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Today, pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide with a five-year overall survival rate of less than 7%. Only 15–20% of patients are eligible for curative intent surgery at the time of diagnosis. Therefore, neoadjuvant treatment regimens have been introduced in order to downsize the tumor by chemotherapy and radiotherapy. To further increase the efficacy of radiotherapy, novel molecular biomarkers are urgently needed to define the subgroup of pancreatic cancer patients who would benefit most from radiotherapy. MicroRNAs (miRNAs) could have the potential to serve as novel predictive and prognostic biomarkers in patients with pancreatic cancer. In the present article, the role of miRNAs as blood biomarkers, which are associated with either radioresistance or radiation-induced changes of miRNAs in pancreatic cancer, is discussed. Furthermore, the manuscript provides own data of miRNAs identified in a pancreatic cancer mouse model as well as radiation-induced miRNA changes in the plasma of tumor-bearing mice.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Biomarker ; Mirna ; Pancreatic Cancer ; Personalized Medicine ; Radioresistance ; Radiotherapy ; Target; Cell Lung-cancer; Microrna Expression; Breast-cancer; Increases Radiosensitivity; Promotes Proliferation; Ductal Adenocarcinoma; Diagnostic Biomarkers; Potential Biomarker; Carcinoma-cells; Down-regulation
ISSN (print) / ISBN 2072-6694
Journal Cancers
Quellenangaben Volume: 12, Issue: 12, Pages: , Article Number: 3703 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status Peer reviewed
Grants KKF, Medical Faculty of the Technical University of Munich (TUM)
Helmholtz Zentrum Munchen
German Consortium for Translational Cancer Research
Hans und Klementia Langmatz Stiftung
Medical Faculty of the Technical University of Munich (TUM)
Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
"Translational & Clinical Projects", Helmholtz Zentrum Munchen
Munich/TUM site
Medical Faculty of TUM