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The effect of BMI and type 2 diabetes on socioeconomic status: A two-sample multivariable mendelian randomization study.

Diabetes Care 44, 850-852 (2021)
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Open Access Green
OBJECTIVE: To assess the independent causal effect of BMI and type 2 diabetes (T2D) on socioeconomic outcomes by applying two-sample Mendelian randomization (MR) analysis. RESEARCH DESIGN AND METHODS: We performed univariable and multivariable two-sample MR to jointly assess the effect BMI and T2D on socioeconomic outcomes. We used overlapping genome-wide significant single nucleotide polymorphisms for BMI and T2D as instrumental variables. Their causal impact on household income and regional deprivation was assessed using summary-level data from the UK Biobank. RESULTS: In the univariable analysis, higher BMI was related to lower income (marginal effect of 1-SD increase in BMI [β = -0.092; 95% CI -0.138; -0.047]) and higher deprivation (β = 0.051; 95% CI 0.022; 0.079). In the multivariable MR, the effect of BMI controlling for diabetes was slightly lower for income and deprivation. Diabetes was not associated with these outcomes. CONCLUSIONS: High BMI, but not diabetes, shows a causal link with socioeconomic outcomes.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 44, Issue: 3, Pages: 850-852 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Reviewing status Peer reviewed