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Ronkainen, J.* ; Heiskala, A.* ; Vehmeijer, F.O.L.* ; Lowry, E.* ; Caramaschi, D.* ; Estrada Gutierrez, G.* ; Heiss, J.A.* ; Hummel, N. ; Keikkala, E.* ; Kvist, T.* ; Kupsco, A.* ; Melton, P.E.* ; Pesce, G.* ; Soomro, M.H.* ; Vives-Usano, M.* ; Baïz, N.* ; Binder, E.* ; Czamara, D.* ; Guxens, M.* ; Mustaniemi, S.* ; London, S.J.* ; Rauschert, S.* ; Vääräsmäki, M.* ; Vrijheid, M.* ; Ziegler, A.G.* ; Annesi-Maesano, I.* ; Bustamante, M.* ; Huang, R.C.* ; Hummel, S.* ; Just, A.C.* ; Kajantie, E.* ; Lahti, J.* ; Lawlor, D.* ; Räikkönen, K.* ; Järvelin, M.R.* ; Felix, J.F.* ; Sebert, S.*

Maternal haemoglobin levels in pregnancy and child DNA methylation: A study in the pregnancy and childhood epigenetics consortium.

Epigenetics 17, 19-31 (2022)
Verlagsversion Forschungsdaten DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analyzed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 children and 1,962 adolescent whole-blood samples derived from 10 cohorts. DNA methylation was measured using Illumina Infinium Methylation 450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for the association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dna Methylation ; Maternal Haemoglobin ; Developmental Programming ; Pregnancy
ISSN (print) / ISBN 1559-2294
e-ISSN 1559-2308
Zeitschrift Epigenetics
Quellenangaben Band: 17, Heft: 1, Seiten: 19-31 Artikelnummer: , Supplement: ,
Verlag Landes Bioscience
Verlagsort Austin, Tex.
Begutachtungsstatus Peer reviewed
Förderungen European Union's Horizon 2020
Novo Nordisk Foundation
Foundation for Pediatric Research
Horizon2020 grant for RECAP Research on Children and Adults Born Preterm
UK Medical Research Council
National Institute of Environmental Health Sciences
Biocenter Oulu
Academy of Finland
Signe and Ane Gyllenberg Foundation
Sigrid Juselius Foundation
Department of Health, Western Australia FutureHealth fund
National Health and Medical Research Council EU
University of Oulu Graduate School
National Institutes of Health, National Institute of Environmental Health Sciences
National Health and Medical Research Council Fellowship Grants
Juho Vainio Foundation
Research Funds of Oulu University Hospital
Miguel Servet fellowship from the Institute of Health Carlos III
Finnish Medical Association
European Union's Horizon 2020 research and innovation program