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Brandes, R.P.* ; Dueck, A.* ; Engelhardt, S.* ; Kaulich, M.* ; Kupatt, C.* ; De Angelis, M.T.* ; Leisegang, M.S.* ; le Noble, F.* ; Moretti, A.* ; Müller, O.J.* ; Skryabin, B.V.* ; Thum, T.* ; Wurst, W.

DGK and DZHK position paper on genome editing: Basic science applications and future perspective.

Basic Res. Cardiol. 116:2 (2021)
Verlagsversion DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
For a long time, gene editing had been a scientific concept, which was limited to a few applications. With recent developments, following the discovery of TALEN zinc-finger endonucleases and in particular the CRISPR/Cas system, gene editing has become a technique applicable in most laboratories. The current gain- and loss-of function models in basic science are revolutionary as they allow unbiased screens of unprecedented depth and complexity and rapid development of transgenic animals. Modifications of CRISPR/Cas have been developed to precisely interrogate epigenetic regulation or to visualize DNA complexes. Moreover, gene editing as a clinical treatment option is rapidly developing with first trials on the way. This article reviews the most recent progress in the field, covering expert opinions gathered during joint conferences on genome editing of the German Cardiac Society (DGK) and the German Center for Cardiovascular Research (DZHK). Particularly focusing on the translational aspect and the combination of cellular and animal applications, the authors aim to provide direction for the development of the field and the most frequent applications with their problems.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Animal Models ; Animal Models ; Crispr/cas ; Genome Editing
ISSN (print) / ISBN 0300-8428
e-ISSN 1435-1803
Quellenangaben Band: 116, Heft: 1, Seiten: , Artikelnummer: 2 Supplement: ,
Verlag Springer
Verlagsort Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Begutachtungsstatus Peer reviewed
Förderungen DZHK
Projekt DEAL