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Baboota, R.K.* ; Blüher, M. ; Smith, U.*

Emerging role of bone morphogenetic protein 4 in metabolic disorders.

Diabetes 70, 303-312 (2021)
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Free by publisher: Publ. Version/Full Text online available 03/2022
Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regulator of white/beige adipogenic differentiation with important consequences for thermogenesis, energy homeostasis, and development of obesity in vivo. BMP4 is highly expressed in, and released by, human adipose tissue, and serum levels are increased in obesity. Recent studies have now shown BMP4 to play an important role not only for white/beige/brown adipocyte differentiation and thermogenesis but also in regulating systemic glucose homeostasis and insulin sensitivity. It also has important suppressive effects on hepatic glucose production and lipid metabolism. Cellular BMP4 signaling/action is regulated by both ambient cell/systemic levels and several endogenous and systemic BMP antagonists. Reduced BMP4 signaling/action can contribute to the development of obesity, insulin resistance, and associated metabolic disorders. In this article, we summarize the pleiotropic functions of BMP4 in the pathophysiology of these diseases and also consider the therapeutic implications of targeting BMP4 in the prevention/treatment of obesity and its associated complications.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Stellate Cell Activation; Growth-factor-beta; Bmp4 Gene-therapy; Adipose-tissue; Hypertrophic Obesity; Insulin Sensitivity; Liver-disease; White; Expression; Adipogenesis
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 70, Issue: 2, Pages: 303-312 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants West Sweden ALF program
Swedish Diabetes Foundation
Torsten Soderberg Foundation
Novo Nordisk Foundation
Swedish Research Council