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Dietz, S.* ; Schwarz, J.* ; Rühle, J.* ; Schaller, M.* ; Fehrenbacher, B.* ; Marmé, A.* ; Schmid, E.* ; Peter, A. ; Poets, C.F.* ; Gille, C.* ; Köstlin-Gille, N.*

Extracellular vesicles released by myeloid-derived suppressor cells from pregnant women modulate adaptive immune responses.

Cell. Immunol. 361:104276 (2021)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Immunological pregnancy complications are a main challenge in reproductive medicine. Mechanisms regulating the adaptation of the maternal immune system to pregnancy are incompletely understood and therapeutic options limited. Myeloid derived suppressor cells (MDSC) are immune-modulatory cells expanding during healthy pregnancy and seem to play a crucial role for maternal-fetal tolerance. Recent studies showed that exosomes produced by MDSC have immune-modulatory effects corresponding to their parental cells under different pathological conditions. Here, we investigated immunological effects of exosomes of GR-MDSC during pregnancy. Isolated GR-MDSC exosomes from peripheral blood of pregnant women were tested for functionality in different in vitro assays. We show that GR-MDSC exosomes exhibited profound immune-modulatory effects such as suppression of T-cell proliferation, T helper 2 (Th2)-cell polarization, induction of regulatory T-cells and inhibition of lymphocyte cytotoxicity. Our results confirm that MDSC-derived exosomes functionally correspond to their parental cells and identify them as an interesting therapeutic target for immunological pregnancy complications.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Extracellular Vesicles ; Mdsc ; Pregnancy ; Th-cells ; Tregs
ISSN (print) / ISBN 0008-8749
e-ISSN 0008-8749
Zeitschrift Cellular Immunology
Quellenangaben Band: 361, Heft: , Seiten: , Artikelnummer: 104276 Supplement: ,
Verlag Elsevier
Verlagsort 525 B St, Ste 1900, San Diego, Ca 92101-4495 Usa
Begutachtungsstatus Peer reviewed
Förderungen German Center for Infection Research (DZIF)
Federal Ministry of Education and Research (BMBF)
German Research Foundation (DFG)
European Social Fund
Ministry for Science, Research and Art Baden-Wurttemberg (MWK-BW)
Medical Faculty of Tuebingen University