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Schültke, E.* ; Bayat, S.* ; Bartzsch, S. ; Bräuer-Krisch, E.* ; Djonov, V.* ; Fiedler, S.* ; Fernandez-Palomo, C.* ; Jaekel, F.* ; Pellicioli, P.* ; Trappetti, V.* ; Hildebrandt, G.*

A mouse model for microbeam radiation therapy of the lung.

Int. J. Radiat. Oncol. Biol. Phys. 110, 521-525 (2021)
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Creative Commons Lizenzvertrag
Open Access Green: Postprint online available 02/2022
Purpose: Radiation therapy is an important treatment component for patients with lung cancer. However, the survival time gained with clinical radiation therapy techniques is relatively short. Data from preclinical experiments suggest that synchrotron microbeam radiation therapy could be much better suited to control malignant brain tumors than current clinical concepts of radiation therapy. Even at peak doses of several hundred gray, the extent of functional deficits is low. Methods and Materials: We have developed the first mouse model to study the effects of microbeam irradiation in lung tissue. Results: Up to peak doses of 400 Gy, no acute adverse effects were seen. Conclusion: This model is well suited to explore the potential of microbeam radiation therapy in the treatment of lung cancer and the response of normal lung tissue and organs at risk.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Radiotherapy; Uniform
ISSN (print) / ISBN 0360-3016
e-ISSN 0360-3016
Quellenangaben Volume: 110, Issue: 2, Pages: 521-525 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Reviewing status Peer reviewed
Grants Deutsche Forschungsgemeinschaft (DFG) , Germany