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Trefzer, A.* ; Kadam, P.* ; Wang, S.H.* ; Pennavaria, S.* ; Lober, B.* ; Akçabozan, B.* ; Kranich, J.* ; Brocker, T.* ; Nakano, N.* ; Irmler, M. ; Beckers, J. ; Straub, T.* ; Obst, R.*

Dynamic adoption of anergy by antigen-exhausted CD4+ T cells.

Cell Rep. 34:108748 (2021)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
In a system with regulatable antigen presentation in vivo, Trefzer et al. find TCR signaling, gene transcription, and functionalities reversibly regulated by dose and time of chronically persisting antigen. Comparisons with naturally anergic and tumor-infiltrating T cells suggest that signatures of anergy and exhaustion by antigen largely overlap.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Anergy ; Cd4 T Cells + ; Exhaustion ; Gene Expression ; Microarray ; T Cell Receptor ; Tolerance ; Transcriptomics ; Tuning; Chronic Viral-infections; Cutting Edge; Lymphocyte-activation; Dendritic Cells; B-cells; Tcr; Cd8; Transcription; Expression; Responses
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Zeitschrift Cell Reports
Quellenangaben Band: 34, Heft: 6, Seiten: , Artikelnummer: 108748 Supplement: ,
Verlag Cell Press
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Förderungen Helmholtz Alliance ``Aging and Metabolic Programming, AMPro''
German Research Council (Deutsche Forschungsgemeinschaft)