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The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.

Cell Rep. 34:108742 (2021)
Publ. Version/Full Text Research data DOI
Open Access Gold
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The Authors Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis-regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Compass Complex ; Dexamethasone ; Enhancers ; Genomics ; Glucocorticoid Receptor ; H3k4 Methylation ; Inflammation ; Macrophages ; Setd1a ; Transcription; Histone H3; Binding Protein; Methyltransferase Complex; Saccharomyces-cerevisiae; Chromatin Accessibility; Molecular Regulation; Set1 Complex; Phd Finger; R Package; Gene
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 34, Issue: 6, Pages: , Article Number: 108742 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Grants ERC