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A method for the establishment and characterization of mouse lung adenocarcinoma cell lines that mimic traits of human adenocarcinomas.
In: Lung Cancer. Berlin [u.a.]: Springer, 2021. 175-186 (Methods Mol. Biol. ; 2279)
Lung adenocarcinoma (LADC) is the leading cause of cancer death worldwide and is largely inflicted by carcinogens contained in tobacco smoke. The generation of cell lines mimicking traits of human LADC will profoundly advance our understanding of the pathobiology of the disease, as they offer an easy and valuable tool to study the cellular and molecular aspects of carcinogenesis. Here we describe a detailed protocol for the generation of such cell lines, following the exposure of experimental mouse strains to different tobacco carcinogens and isolation of the resulting lung tumors.
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Publication type Article: Edited volume or book chapter
Keywords Chemical Carcinogenesis ; Lung Adenocarcinoma ; Mouse Cell Lines ; Smoke-induced Carcinogenesis ; Tobacco Smoke
ISSN (print) / ISBN 1064-3745
Book Volume Title Lung Cancer
Journal Methods in Molecular Biology
Quellenangaben Volume: 2279, Pages: 175-186
Publishing Place Berlin [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Lung Biology (ILBD)