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Vishram-Nielsen, J.K.K.* ; Kristensen, A.M.D.* ; Pareek, M.* ; Laurent, S.* ; Nilsson, P.M.* ; Linneberg, A.* ; Greve, S.V.* ; Palmieri, L.* ; Giampaoli, S.* ; Donfrancesco, C.* ; Kee, F.* ; Mancia, G.* ; Cesana, G.* ; Veronesi, G.* ; Grassi, G.* ; Kuulasmaa, K.* ; Salomaa, V.* ; Palosaari, T.* ; Sans, S.* ; Ferrieres, J.* ; Dallongeville, J.* ; Söderberg, S.* ; Moitry, M.* ; Drygas, W.* ; Tamosiunas, A.* ; Peters, A. ; Brenner, H.* ; Grimsgaard, S.* ; Savallampi, M.* ; Olsen, M.H.*

Predictive importance of blood pressure characteristics with increasing age in healthy men and women: The MORGAM Project.

Hypertension 77, 1076-1085 (2021)
Postprint DOI
Open Access Green
National licence: Publ. Version/Full Text online available 04/2023
It remains unclear which blood pressure (BP) characteristics best predict cardiovascular risk in different age groups and between sexes. We leveraged data from the MORGAM (MONICA [Monitoring of Trends and Determinants in Cardiovascular Disease], Risk, Genetics, Archiving and Monograph) Project to investigate determinants of BP characteristics and their prognostic importance, in younger and older (P interaction <0.001). Higher systolic BP and mean BP were significantly associated with cardiovascular end point, irrespective of age group (P<0.001), but diastolic BP only demonstrated an independent relationship in the younger group (P<0.001). Brachial pulse pressure was associated with cardiovascular end point in the older age group (P<0.001). In subjects <50 years, diastolic BP significantly improved area under the receiver operating characteristic curve compared with Systematic Coronary Risk Evaluation variables (including systolic BP) alone (0.842 versus 0.840, P=0.03), enhanced continuous net reclassification improvement (0.150 [95% CI, 0.087-0.215]) and improved the prognostic value of the European Society of Cardiology/European Society of Hypertension hypertension definition (categorical net reclassification improvement=0.0255, P=0.005). In conclusion, diastolic BP may provide additional prognostic utility beyond systolic BP, in predicting composite cardiovascular events among younger individuals.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Blood Pressure ; Cardiovascular Disease ; Myocardial Infarction ; Prognosis ; Risk Factor
ISSN (print) / ISBN 0194-911x
e-ISSN 1524-4563
Journal Hypertension
Quellenangaben Volume: 77, Issue: 4, Pages: 1076-1085 Article Number: , Supplement: ,
Publisher Lippincott Williams & Wilkins
Publishing Place Two Commerce Sq, 2001 Market St, Philadelphia, Pa 19103 Usa
Reviewing status Peer reviewed
Grants County council of Vastertbotten
Swedish Heart and Lung Foundation
Finnish Foundation for Cardiovascular research
European Community FP 7 projects Consortium on Health and Ageing: Network of cohorts in Europe and the United States