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Apaolaza Gallegos, S.P. ; Balcacean, D. ; Zapardiel-Gonzalo, J. ; Nelson, G.* ; Lenchik, N.* ; Akhbari, P.* ; Gerling, I.* ; Richardson, S.J.* ; Rodriguez-Calvo, T.

Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes.

Sci. Adv. 7:eabd6527 (2021)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes (T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we determined the expression of the IFN response markers MxA, PKR, and HLA-I in the islets of autoantibody-positive and T1D donors. We found that these markers can be coexpressed in the same islet, are more abundant in insulin-containing islets, are highly expressed in islets with insulitis, and their expression levels are correlated with the presence of the enteroviral protein VP1. The expression of these markers was associated with down-regulation of multiple genes in the insulin secretion pathway. The coexistence of an IFN response and a microbial stress response is likely to prime islets for immune destruction. This study highlights the importance of therapeutic interventions aimed at eliminating potentially persistent infections and diminishing inflammation in individuals with T1D.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 2375-2548
e-ISSN 2375-2548
Quellenangaben Volume: 7, Issue: 9, Pages: , Article Number: eabd6527 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington, DC [u.a.]
Reviewing status Peer reviewed