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Miranda Rodriguez, J.R. ; Schnabel, D.*

Applying rho pathway inhibitors to investigate germ plasm localization.

In: Germline Development in the Zebrafish. Berlin [u.a.]: Springer, 2021. 85-97 (Methods Mol. Biol. ; 2218)
Open Access Green as soon as Postprint is submitted to ZB.
The correct assembly, migration, and segregation of the mRNAs of the germ plasm during the first cell divisions are intimately connected to the cytoskeleton and cytokinesis.RhoA is a key regulator of germ plasm localization during the first two cell division cycles in zebrafish embryos. Pharmacological inhibition of RhoA and his effector ROCK affected the correct assembly of microtubules in the cleavage furrow with the concomitant abnormal localization of germ plasm mRNAs. The inhibition of RhoA/ROCK pathway caused a significant decrease in the germ cell population later in development.
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Publication type Article: Edited volume or book chapter
Keywords Cytoskeleton ; Germ Line ; Rock ; Rho Gtpases ; Rhoa ; Zebrafish ; Mrna Localization
ISSN (print) / ISBN 1064-3745
e-ISSN 1940-6029
Book Volume Title Germline Development in the Zebrafish
Quellenangaben Volume: 2218, Issue: , Pages: 85-97 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin [u.a.]
Reviewing status Peer reviewed