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Harwalkar, K.* ; Ford, M.J.* ; Teng, K.* ; Yamanaka, N.* ; Yang, B.* ; Burtscher, I. ; Lickert, H. ; Yamanaka, Y.*

Anatomical and cellular heterogeneity in the mouse oviduct- its potential roles in reproduction and preimplantation development.

Biol. Reprod. 104, 1249-1261 (2021)
DOI Verlagsversion bestellen
Free by publisher: Verlagsversion online verfügbar 05/2022
The oviduct/fallopian tube is a tube-like structure that extends from the uterus to the ovary. It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction (UTJ) that likely play roles in reproduction. Further, we demarcated the ampulla-isthmus junction (AIJ) as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Fallopian Tube ; Luminal Epithelium ; Luminal Folds ; Oviduct ; Preimplantation Development ; Sperm Reservoir; Common Marmoset; Sperm Reservoir; Epithelium; Endoderm; Features; Isthmus; Embryo; Cells
ISSN (print) / ISBN 0006-3363
e-ISSN 1529-7268
Quellenangaben Band: 104, Heft: 6, Seiten: 1249-1261 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Journals Dept, 2001 Evans Rd, Cary, Nc 27513 Usa
Begutachtungsstatus Peer reviewed
Förderungen Canderel graduate studentship
CCS innovation to Impact (i2I) Grant
Cancer Research Society Operation Grant
Centre for Research in Reproductuion and Development (CRRD)
Rolande & Marcel Gosselin graduate studentship
Canderel
CRRD
Fonds de recherche du Quebec - Sante (FRQS)
McGill Integrated Cancer Research Training (MICRTP) studentship
Canadian Cancer Society (CCS) Innovation Grant (Haladner Memorial Foundation)