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Moruzzi, M.* ; Klöting, N. ; Blüher, M. ; Martinelli, I.* ; Tayebati, S.K.* ; Gabrielli, M.G.* ; Roy, P.* ; Micioni Di Bonaventura, M.V.* ; Cifani, C.* ; Lupidi, G.* ; Amenta, F.* ; Tomassoni, D.*

Tart cherry juice and seeds affect pro-inflammatory markers in visceral adipose tissue of high-fat diet obese rats.

Molecules 26:1403 (2021)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Background: Tart cherries (Prunus cerasus L.) are a rich source of anthocyanins. They are phytochemical flavonoids found in red and blue fruits, and vegetables that can reduce hyperlipidemia. Visceral Adipose Tissue (VAT) has emerged as a major player in driving obesity-related inflammatory response. Methods: This study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed ad libitum for 17 weeks with a hypercaloric diet with the supplementation of tart cherries seeds powder (DS) and seeds powder plus tart cherries juice containing 1mg of anthocyanins (DJS). In RPW and PGW, expression of CRP, IL-1 beta, TNF-alpha, CCL2 and CD36, were measured by qRT-PCR, Western blot and immunohistochemistry techniques. Results: No differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation. Conclusion: Study results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Obesity ; Visceral Adipose Tissue ; Inflammation ; Tart Cherries
ISSN (print) / ISBN 1420-3049
e-ISSN 1420-3049
Journal Molecules
Quellenangaben Volume: 26, Issue: 5, Pages: , Article Number: 1403 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants University of Camerino