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Sampath, V.* ; Rabinowitz, G.* ; Shah, M.* ; Jain, S.* ; Diamant, Z.* ; Jesenak, M.* ; Rabin, R.* ; Vieths, S.* ; Agache, I.* ; Akdis, M.* ; Barber, D.* ; Breiteneder, H.* ; Chinthrajah, S.* ; Chivato, T.* ; Collins, W.* ; Eiwegger, T.* ; Fast, K.* ; Fokkens, W.* ; O'Hehir, R.E.* ; Ollert, M.* ; O'Mahony, L.* ; Palomares, O.* ; Pfaar, O.* ; Riggioni, C.* ; Shamji, M.H.* ; Sokolowska, M.* ; Torres, M.J.* ; Traidl-Hoffmann, C. ; van Zelm, M.* ; Wang, Y.* ; Zhang, L.* ; Akdis, C.* ; Nadeau, K.C.*

Vaccines and Allergic reactions: The past, the current COVID-19 pandemic, and future perspectives.

Allergy 76, 1640-1660 (2021)
Postprint DOI
Open Access Green
Free by publisher: Publ. Version/Full Text online available 05/2023
Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur aftervaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.
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Publication type Article: Journal article
Document type Review
Keywords Covid-19 ; Sars-cov-2 ; Allergy ; Anaphylaxis ; Vaccine; Protein-coupled Receptor-x2; Anti-peg Antibodies; Mast-cell; Hypersensitivity Reactions; Adverse-reactions; Safety Data; Anaphylaxis; Vaccination; Children; Gelatin
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 76, Issue: 6, Pages: 1640-1660 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)
Grants NIAID SARS Vaccine study
Crown Foundation
Sunshine foundation
Parker foundation