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Liu, N. ; Gujrati, V. ; Malekzadeh-Najafabadi, J.* ; Werner, J.P,F. ; Klemm, U. ; Tang, L.* ; Chen, Z.* ; Prakash, J. ; Huang, Y. ; Stiel, A.-C. ; Mettenleiter, G. ; Aichler, M. ; Blutke, A. ; Walch, A.K. ; Kleigrewe, K.* ; Razansky, D.* ; Sattler, M. ; Ntziachristos, V.

Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors.

Photoacoustics 22:100263 (2021)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Contrast enhancement in optoacoustic (photoacoustic) imaging can be achieved with agents that exhibit high absorption cross-sections, high photostability, low quantum yield, low toxicity, and preferential bio-distribution and clearance profiles. Based on advantageous photophysical properties of croconaine dyes, we explored croconaine-based nanoparticles (CR780RGD-NPs) as highly efficient contrast agents for targeted optoacoustic imaging of challenging preclinical tumor targets. Initial characterization of the CR780 dye was followed by modifications using polyethylene glycol and the cancer-targeting c(RGDyC) peptide, resulting in self-assembled ultrasmall particles with long circulation time and active tumor targeting. Preferential bio-distribution was demonstrated in orthotopic mouse brain tumor models by multispectral optoacoustic tomography (MSOT) imaging and histological analysis. Our findings showcase particle accumulation in brain tumors with sustainable strong optoacoustic signals and minimal toxic side effects. This work points to CR780RGD-NPs as a promising optoacoustic contrast agent for potential use in the diagnosis and image-guided resection of brain tumors.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Brain Tumor ; Croconaine ; Msot ; Nanoparticles ; Optoacoustic (photoacoustic) Imaging; In-vivo; Contrast Agents; Mouse-brain; Tomography; Deep; Accumulation; Fluorescence; Oxygenation; Squaraine; Probes
ISSN (print) / ISBN 2213-5979
Journal Photoacoustics
Quellenangaben Volume: 22, Issue: , Pages: , Article Number: 100263 Supplement: ,
Publisher Elsevier
Publishing Place Hackerbrucke 6, 80335 Munich, Germany
Reviewing status Peer reviewed
Grants Alexander von Humboldt Postdoctoral Fellowship
China Scholarship Council
Deutsche Forschungsgemeinschaft (DFG), Germany (Gottfried Wilhelm Leibniz Prize 2013)
European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme