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Tomographic optoacoustic inversion in dynamic illumination scenarios.

Proc. SPIE 7899:78991Y (2011)
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Obtaining quantified optoacoustic reconstructions is an important and longstanding challenge, mainly caused by the complex heterogeneous structure of biological tissues as well as the lack of accurate and robust reconstruction algorithms. The recently introduced model-based inversion approaches were shown to eliminate some of reconstruction artifacts associated with the commonly used back-projection schemes, while providing an excellent platform for obtaining quantified maps of optical energy deposition in experimental configurations of various complexity. In this work, we introduce a weighted model-based approach, capable of overcoming reconstruction challenges caused by perprojection variations of object's illumination and other partial illumination effects. The universal weighting procedure is equally shown to reduce reconstruction artifacts associated with other experimental imperfections, such as non-uniform transducer sensitivity fields. Significant improvements in image fidelity and quantification are showcased both numerically and experimentally on tissue phantoms.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Inversion Schemes ; Light Diffusion ; Optoacoustic Imaging
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Quellenangaben Volume: 7899, Issue: , Pages: , Article Number: 78991Y Supplement: ,
Publisher SPIE
Publishing Place Bellingham, WA
Reviewing status Peer reviewed