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Linseisen, J. ; Grundmann, N. ; Zoller, D.* ; Kuhn, T.* ; Jansen, E.H.J.M.* ; Chajes, V.* ; Fedirko, V.* ; Weiderpass, E.* ; Dahm, C.C.* ; Overvad, K.* ; Tjønneland, A.* ; Boutron-Ruault, M.C.* ; Rothwell, J.A.* ; Severi, G.* ; Kaaks, R.* ; Schulze, M.B.* ; Aleksandrova, K.* ; Sieri, S.* ; Panico, S.* ; Tumino, R.* ; Masala, G.* ; de Marco, L.* ; Bueno-de-Mesquita, B.* ; Vermeulen, R.* ; Gram, I.T.* ; Skeie, G.* ; Chirlaque, M.D.* ; Ardanaz, E.* ; Agudo, A.* ; Sánchez, M.J.* ; Amiano, P.* ; Wennberg, M.* ; Bodén, S.* ; Perez-Cornago, A.* ; Aglago, E.K.* ; Gunter, M.J.* ; Jenab, M.* ; Heath, A.K.* ; Nieters, A.*

Red blood cell fatty acids and risk of colorectal cancer in the European Prospective investigation into cancer and nutrition (EPIC).

Cancer Epidemiol. Biomarkers Prev. 30, 874-885 (2021)
DOI Order publishers version
Open Access Green: Postprint online available 06/2022
Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. Methods: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case–control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of colorectal cancer was estimated by multivariable adjusted conditional logistic regression models. Results: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for colorectal cancer (OR ¼ 1.23; 95% CI ¼ 1.07–1.42, per 1 mol%). Conversely, colorectal cancer incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62–0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent. Conclusions: The positive association between prediagnostic RBC stearic acid and colorectal cancer reflects putative differences in FA intake and metabolism between cancer cases and matched controls, which deserve further investigation. The inverse relationship between EPA and colorectal cancer is in line with the repeatedly reported protective effect of fish consumption on colorectal cancer risk. Impact: These findings add to the evidence on colorectal cancer prevention.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Dietary-fat; Biomarkers; Plasma; Colon; Mechanisms; Prevention; Rationale; Apoptosis; Synthase
ISSN (print) / ISBN 1055-9965
e-ISSN 1538-7755
Quellenangaben Volume: 30, Issue: 5, Pages: 874-885 Article Number: , Supplement: ,
Publisher American Association for Cancer Research (AACR)
Publishing Place 615 Chestnut St, 17th Floor, Philadelphia, Pa 19106-4404 Usa
Reviewing status Peer reviewed
Grants Dutch Prevention Funds
Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds
National Research Council (Italy)
Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy
Hellenic Health Foundation (Greece)
Federal Ministry of Education and Research (Germany)
Deutsche Krebshilfe
German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF)
German Cancer Aid
Institut Gustave Roussy
Ligue contre le Cancer
Danish Cancer Society (Denmark)
International Agency for Research on Cancer
European Commission (DG-SANCO)
Dutch ZON (Zorg Onderzoek Nederland)
World Cancer Research Fund (WCRF), Statistics Netherlands (the Netherlands)
Medical Research Council
Cancer Research UK
Swedish Research Council
Swedish Cancer Society
FEDER funds/European Regional Development Fund (ERDF) "A Way to Build Europe
Red Tematica de Investigacion Cooperativa en Cancer of the Instituto de Salud Carlos III
AGAUR, Generalitat de Catalunya
Catalan Institute of Oncology -ICO, ISCIII RETIC
Health Research Fund (FIS)
German Cancer Aid (Deutsche Krebshilfe)