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Aldrovandi, M. ; Fedorova, M.* ; Conrad, M.

Juggling with lipids, a game of Russian roulette.

Trends Endocrinol. Metab. 32, 463-473 (2021)
DOI Verlagsversion bestellen
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Lipid peroxidation (LPO) is the molecular mechanism involved in oxidative damage of cellular membranes and the hallmark of a nonapoptotic form of cell death, known as ferroptosis. This iron-dependent cell death is an emerging strategy in cancer treatment and one of the central cell death mechanisms accounting for early cell loss and organ dysfunction in both neurodegenerative disease and ischemia-reperfusion injury. Although the biological roles of LPO products have attracted considerable attention, not only for their pathological mechanisms but also for their potential clinical application as biomarkers, the existence of a common lethal lipid death signal generated during ferroptosis remains poorly explored. A better understanding of the LPO process, however, may unleash unprecedented opportunities for therapeutic intervention of as-yet incurable diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Ferroptosis ; Lipid Metabolism ; Lipid Peroxidation ; Polyunsaturated Fatty Acids ; Reactive Oxygen Species; Generating Enzyme Agps; Ether Lipids; Promotes Ferroptosis; Peroxidation; Sensitivity; Mechanisms; Cells; Iron; Susceptibility; Inhibitors
ISSN (print) / ISBN 1043-2760
e-ISSN 1879-3061
Quellenangaben Band: 32, Heft: 7, Seiten: 463-473 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 84 Theobalds Rd, London Wc1x 8rr, England
Begutachtungsstatus Peer reviewed
Förderungen Deutsche Forschungsgemeinschaft (DFG)
German Federal Ministry of Education and Research (BMBF) VIP+ program NEUROPROTEKT
Ministry of Science and Higher Education of The Russian Federation
Else Kroner-Fresenius-Stiftung
European Research Council (ERC) under the European Union
BMBF