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Aldrovandi, M. ; Fedorova, M.* ; Conrad, M.

Juggling with lipids, a game of Russian roulette.

Trends Endocrinol. Metab. 32, 463-473 (2021)
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Open Access Green as soon as Postprint is submitted to ZB.
Lipid peroxidation (LPO) is the molecular mechanism involved in oxidative damage of cellular membranes and the hallmark of a nonapoptotic form of cell death, known as ferroptosis. This iron-dependent cell death is an emerging strategy in cancer treatment and one of the central cell death mechanisms accounting for early cell loss and organ dysfunction in both neurodegenerative disease and ischemia-reperfusion injury. Although the biological roles of LPO products have attracted considerable attention, not only for their pathological mechanisms but also for their potential clinical application as biomarkers, the existence of a common lethal lipid death signal generated during ferroptosis remains poorly explored. A better understanding of the LPO process, however, may unleash unprecedented opportunities for therapeutic intervention of as-yet incurable diseases.
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Publication type Article: Journal article
Document type Review
Keywords Ferroptosis ; Lipid Metabolism ; Lipid Peroxidation ; Polyunsaturated Fatty Acids ; Reactive Oxygen Species; Generating Enzyme Agps; Ether Lipids; Promotes Ferroptosis; Peroxidation; Sensitivity; Mechanisms; Cells; Iron; Susceptibility; Inhibitors
ISSN (print) / ISBN 1043-2760
e-ISSN 1879-3061
Quellenangaben Volume: 32, Issue: 7, Pages: 463-473 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 84 Theobalds Rd, London Wc1x 8rr, England
Reviewing status Peer reviewed
Grants Deutsche Forschungsgemeinschaft (DFG)
German Federal Ministry of Education and Research (BMBF) VIP+ program NEUROPROTEKT
Ministry of Science and Higher Education of The Russian Federation
Else Kroner-Fresenius-Stiftung
European Research Council (ERC) under the European Union