PuSH - Publikationsserver des Helmholtz Zentrums München

Buchmann, B.* ; Engelbrecht, L.K. ; Fernandez, P.* ; Hutterer, F.P.* ; Raich, M.K.* ; Scheel, C. ; Bausch, A.R.*

Mechanical plasticity of collagen directs branch elongation in human mammary gland organoids.

Nat. Commun. 12:2759 (2021)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Epithelial branch elongation is a central developmental process during branching morphogenesis in diverse organs. This fundamental growth process into large arborized epithelial networks is accompanied by structural reorganization of the surrounding extracellular matrix (ECM), well beyond its mechanical linear response regime. Here, we report that epithelial ductal elongation within human mammary organoid branches relies on the non-linear and plastic mechanical response of the surrounding collagen. Specifically, we demonstrate that collective back-and-forth motion of cells within the branches generates tension that is strong enough to induce a plastic reorganization of the surrounding collagen network which results in the formation of mechanically stable collagen cages. Such matrix encasing in turn directs further tension generation, branch outgrowth and plastic deformation of the matrix. The identified mechanical tension equilibrium sets a framework to understand how mechanical cues can direct ductal branch elongation.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Extracellular-matrix; Cell; Migration; Dynamics; Morphogenesis; Expression; Tube; Intercalation; Deformation; Integrin
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 12, Heft: 1, Seiten: , Artikelnummer: 2759 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Förderungen Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme