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Dem Anfang auf der Spur — die Suche nach DNA-Replikationsursprüngen.

On the trail of the beginning - The search for DNA replication origins.

BioSpektrum 27, 246-249 (2021)
Publ. Version/Full Text DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Timely and accurate duplication of DNA prior to cell division is a prerequisite for propagation of the genetic material to both daughter cells. DNA synthesis initiates at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, a uniform method that identifies origins of replication in a comprehensive manner is still missing. Here, we present currently available and discuss new approaches to map replication origins in mammalian genomes.
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Publication type Article: Journal article
Document type Review
ISSN (print) / ISBN 0947-0867
e-ISSN 1868-6249
Journal BioSpektrum
Quellenangaben Volume: 27, Issue: 3, Pages: 246-249 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed