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Distinct fibroblasts in scars and regeneration.

Curr. Opin. Genet. Dev. 70, 7-14 (2021)
DOI Verlagsversion bestellen
Open Access Green: Postprint online verfügbar 06/2022
The skin is home to a collection of fibroblastic cell types from varying embryonic origins. These varying fibroblastic lineages display unique genetic programs and in vivo functions. Studying the diversity of fibroblastic cells is emerging as an important area for cutaneous biology, wound repair and regenerative medicine. In this mini-review we discuss the distinct embryonic origins, microenvironments, and transcriptomic profiles of fibroblastic lineages, and how these varying lineages shape the skin's wound response across injury depths, anatomic locations, and developmental time to promote either scarring or regeneration. We outline how the development of single cell sequencing has led to our improved understanding of fibroblastic lineages at the molecular level and discuss existing challenges and future outlook on developing regenerative therapies that are based on this emerging field of eclectic fibroblasts.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Heterogeneity
ISSN (print) / ISBN 0959-437X
e-ISSN 1879-0380
Quellenangaben Band: 70, Heft: , Seiten: 7-14 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 84 Theobalds Rd, London Wc1x 8rr, England
Begutachtungsstatus Peer reviewed
Förderungen European Research Council consolidator grant (ERC-COG)
German Research Foundation
Human Frontier Science Program Career Development Award