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Alboushi, L.* ; Hackett, A.P.* ; Naeli, P.* ; Bakhti, M. ; Jafarnejad, S.M.*

Multifaceted control of mRNA translation machinery in cancer.

Cell. Signal. 84:110037 (2021)
DOI Verlagsversion bestellen
Open Access Green: Postprint online verfügbar 06/2022
The mRNA translation machinery is tightly regulated through several, at times overlapping, mechanisms that modulate its efficiency and accuracy. Due to their fast rate of growth and metabolism, cancer cells require an excessive amount of mRNA translation and protein synthesis. However, unfavorable conditions, such as hypoxia, amino acid starvation, and oxidative stress, which are abundant in cancer, as well as many anti-cancer treatments inhibit mRNA translation. Cancer cells adapt to the various internal and environmental stresses by employing specialised transcript-specific translation to survive and gain a proliferative advantage. We will highlight the major signaling pathways and mechanisms of translation that regulate the global or mRNA-specific translation in response to the intra- or extra-cellular signals and stresses that are key components in the process of tumourigenesis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Cancer ; Elongation ; Initiation ; Mrna Translation ; Protein Synthesis ; Ribosome Recycling ; Signaling Pathway ; Stress ; Termination ; Translation Machinery ; Tumourigenesis; Internal-ribosome-entry; Initiation-factor 4e; Cap-binding Protein; Elongation-factor 2; La-related Protein-1; P70 S6 Kinase; Factor 4e-binding Protein-1; Integrated Stress-response; To-mesenchymal Transition; Ires-mediated Translation
ISSN (print) / ISBN 0898-6568
e-ISSN 0898-6568
Zeitschrift Cellular Signalling
Quellenangaben Band: 84, Heft: , Seiten: , Artikelnummer: 110037 Supplement: ,
Verlag Elsevier
Verlagsort Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Begutachtungsstatus Peer reviewed
Förderungen New Frontiers in Research Fund-Exploration (Canada)
Medical Research Council, United Kingdom (MRC)