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Sucre, J.* ; Haist, L. ; Bolton, C.E.* ; Hilgendorff, A.

Early changes and indicators characterizing lung aging in neonatal chronic lung disease.

Front. Med. 8:665152 (2021)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Infants suffering from neonatal chronic lung disease, i.e., bronchopulmonary dysplasia, are facing long-term consequences determined by individual genetic background, presence of infections, and postnatal treatment strategies such as mechanical ventilation and oxygen toxicity. The adverse effects provoked by these measures include inflammatory processes, oxidative stress, altered growth factor signaling, and remodeling of the extracellular matrix. Both, acute and long-term consequences are determined by the capacity of the immature lung to respond to the challenges outlined above. The subsequent impairment of lung growth translates into an altered trajectory of lung function later in life. Here, knowledge about second and third hit events provoked through environmental insults are of specific importance when advocating lifestyle recommendations to this patient population. A profound exchange between the different health care professionals involved is urgently needed and needs to consider disease origin while future monitoring and treatment strategies are developed.
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Publication type Article: Journal article
Document type Review
Keywords Bronchopulmonary Dysplasia ; Inflammation ; Lung Aging ; Lung Function ; Mechanical Ventilation ; Neonatal Chronic Lung Disease ; Oxygen Toxicity ; Preterm Infant; Kappa-b Activation; Intrauterine Growth Restriction; Resident Alveolar Macrophages; Pulmonary Vascular-disease; Health-care Utilization; Early-onset Sepsis; Bronchopulmonary Dysplasia; Preterm Infants; Risk-factors; Recruited Monocytes
ISSN (print) / ISBN 2296-858X
e-ISSN 2296-858X
Quellenangaben Volume: 8, Issue: , Pages: , Article Number: 665152 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Reviewing status Peer reviewed
Grants doctoral study program Molecular and clinical-translational science (FoFoLe) of the Ludwig Maximilian University Munich
Research Training Group Targets in Toxicology of the German science and research organization (DFG)
German Center for Lung Research (DZL)
Helmholtz Zentrum Muenchen, Germany