PuSH - Publication Server of Helmholtz Zentrum München

Glauche, I.* ; Marr, C.

Mechanistic models of blood cell fate decisions in the era of single-cell data.

Curr. Opin. Syst. Biol., DOI: 10.1016/j.coisb.2021.100355 (2021)
DOI Order publishers version
Open Access Green: Postprint online available 07/2022

Billions of functionally distinct blood cells emerge from a pool of hematopoietic stem cells in our bodies every day. This progressive differentiation process is hierarchically structured and remarkably robust. We provide an introductory review to mathematical approaches addressing the functional aspects of how lineage choice is potentially implemented on a molecular level. Emerging from studies on the mutual repression of key transcription factors we illustrate how those simple concepts have been challenged in recent years and subsequently extended. Especially the analysis of omics data on the single cell level with computational tools provide descriptive insights on a yet unknown level, while their embedding into a consistent mechanistic and mathematical framework is still incomplete.

Altmetric
Additional Metrics?
Edit extra informations Login
Publication type Article: Journal article
Document type Review
Keywords mechanistic model, blood cell decision making, single cell data
ISSN (print) / ISBN 2452-3100
e-ISSN 2452-3100
Publisher Elsevier
Publishing Place Amsterdam
Reviewing status Peer reviewed