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Schwierzeck, V.* ; Hülpüsch, C. ; Reiger, M.

Microbiome of barrier organs in allergy: Who runs the world? Germs!

In:. Berlin ; Heidelberg: Springer, 2021. DOI: 10.1007/164_2021_478 (Handb. Exp. Pharmacol.)
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Over the last few decades, allergic diseases have been steadily increasing worldwide, a phenomenon that is not yet completely understood. Recent evidence, however, suggests that alterations in the microbiome may be a contributing factor. The microbiome refers to all microorganisms in a habitat including bacteria, fungi, and viruses. Using modern sequencing technologies, we are now capable of detecting and analyzing the human microbiome in more detail than ever before. Epidemiological and experimental studies have indicated that a complex intestinal microbiome supports the development of the immune system during childhood, thus providing protection from allergic diseases, including food allergy. The microbiome becomes an important part of human physiology and forms dynamic relationships with our various barrier systems. For example, bacterial dysbiosis is a hallmark of atopic eczema and correlates with disease progression. Similarly, the lung and nasopharyngeal microbiome is altered in patients with asthma and allergic rhinitis. While these results are interesting, the underlying mechanisms are still unclear and need to be investigated with functional studies. This review gives a short overview of the terminology and methods used in microbiome research before highlighting results concerning the lung, skin, and intestinal microbiome in allergic diseases.
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Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Schlagwörter Allergy ; Microbiome ; Sequencing
ISSN (print) / ISBN 0171-2004
Verlag Springer
Verlagsort Berlin ; Heidelberg
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Environmental Medicine (IEM)