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Consequences and resolution of transcription-replication conflicts.

Life 11:637 (2021)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Transcription-replication conflicts occur when the two critical cellular machineries responsible for gene expression and genome duplication collide with each other on the same genomic location. Although both prokaryotic and eukaryotic cells have evolved multiple mechanisms to coordinate these processes on individual chromosomes, it is now clear that conflicts can arise due to aberrant transcription regulation and premature proliferation, leading to DNA replication stress and genomic instability. As both are considered hallmarks of aging and human diseases such as cancer, understanding the cellular consequences of conflicts is of paramount importance. In this article, we summarize our current knowledge on where and when collisions occur and how these encounters affect the genome and chromatin landscape of cells. Finally, we conclude with the different cellular pathways and multiple mechanisms that cells have put in place at conflict sites to ensure the resolution of conflicts and accurate genome duplication.
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Publication type Article: Journal article
Document type Review
Keywords G-mids ; Midas ; R-loops ; Chromatin ; Common Fragile Sites ; Early Replicating Fragile Sites ; Fork Reversal ; Genomic Instability ; Replication Stress ; Torsional Stress ; Transcription–replication Conflicts; Common Fragile Sites; Polymerase-ii Transcription; R-loop Formation; Dna-replication; Facilitates Replication; Ribosomal-rna; S-phase; Genomic Instability; Fork Progression; Messenger-rna
ISSN (print) / ISBN 2075-1729
e-ISSN 2075-1729
Journal Life
Quellenangaben Volume: 11, Issue: 7, Pages: , Article Number: 637 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Grants European Research Council (ERC) under the European Union
Helmholtz Association