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Kellnberger, S.* ; Wissmeyer, G.* ; Albaghdadi, M.* ; Piao, Z.* ; Li, W.* ; Mauskapf, A.* ; Rauschendorfer, P. ; Tearney, G.J.* ; Ntziachristos, V. ; Jaffer, F.A.*

Intravascular molecular-structural imaging with a miniaturized integrated near-infrared fluorescence and ultrasound catheter.

J. Biophotonics, DOI: 10.1002/jbio.202100048 (2021)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Coronary artery disease (CAD) remains a leading cause of mortality and warrants new imaging approaches to better guide clinical care. We report on a miniaturized, hybrid intravascular catheter and imaging system for comprehensive coronary artery imaging in vivo. Our catheter exhibits a total diameter of 1.0 mm (3.0 French), equivalent to standalone clinical intravascular ultrasound (IVUS) catheters but enables simultaneous near-infrared fluorescence (NIRF) and IVUS molecular-structural imaging. We demonstrate NIRF-IVUS imaging in vitro in coronary stents using NIR fluorophores, and compare NIRF signal strengths for prism and ball lens sensor designs in both low and high scattering media. Next, in vivo intravascular imaging in pig coronary arteries demonstrates simultaneous, co-registered molecular-structural imaging of experimental CAD inflammation on IVUS and distance-corrected NIRF images. The obtained results suggest substantial potential for the NIRF-IVUS catheter to advance standalone IVUS, and enable comprehensive phenotyping of vascular disease to better assess and treat patients with CAD.

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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Intravascular Ultrasound ; Intravascular Endoscopy ; Intravascular Imaging ; Near-infrared Imaging; Coronary Atherosclerosis
ISSN (print) / ISBN 1864-063X
e-ISSN 1864-0648
Verlag Wiley
Verlagsort Postfach 101161, 69451 Weinheim, Germany
Begutachtungsstatus Peer reviewed
Förderungen National Institutes of Health
Deutsche Forschungsgemeinschaft
American Heart Association
American College of Cardiology Foundation