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Kalva, S.K.* ; Ron, A. ; Periyasamy, V. ; Reiss, M.* ; Deán-Ben, X.L.* ; Razansky, D.

Whole-body visualization of nanoagent kinetics in mice with flash scanning volumetric optoacoustic tomography.

Proc. SPIE 11642, DOI: 10.1117/12.2577844 (2021)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Visualizing whole-body dynamics across entire living organisms is crucial for understanding complex biology, disease progression as well as evaluating efficacy of new drugs and therapies. Existing small animal functional and molecular imaging modalities either suffer from low spatial and temporal resolution, limited penetration depth or poor contrast. In this work, we present flash scanning volumetric optoacoustic tomography (fSVOT) imaging system that enables the acquisition speeds required for visualizing fast kinetics and biodistribution of optical contrast agents across whole mice. fSVOT can render images of intricate vascular and organ anatomy with rich contrast by capitalizing on the large angular coverage of a spherical matrix array transducer rapidly scanned around the mouse. Volumetric (three-dimensional) images with 200 μm resolution can be acquired within 45 seconds, which corresponds to an imaging speed gain of an order of magnitude with respect to existing state-of-the-art modalities offering comparable resolution performance. We demonstrate volumetric tracking and quantification of gold nanorod kinetics and their differential uptake across the spleen, liver and kidneys. Overall, fSVOT offers unprecedented capabilities for multi-scale imaging of pharmacokinetics and bio-distribution of agents with high contrast, resolution and image acquisition speed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Contrast Agents Biodistribution ; Optoacoustic/photoacoustic Imaging ; Optoacoustic/photoacoustic Tomography ; Whole-body Imaging
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 11642 Heft: , Seiten: , Artikelnummer: , Supplement: ,
Verlag SPIE
Begutachtungsstatus Peer reviewed