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Willems, R.* ; Tsoutsoulopoulou, K.* ; Brondeel, R.* ; Cardon, G.* ; Makrilakis, K.* ; Liatis, S.* ; Lindstrom, J.* ; Kivelä, J.* ; Gonzalez-Gil, E.M.* ; Giménez-Legarre, N.* ; Usheva, N.* ; Iotova, V.* ; Tankova, T.* ; Antal, E.* ; Rurik, I.* ; Timpel, P.* ; Schwarz, P.E. ; Manios, Y.* ; Annemans, L.*

Cost-effectiveness analysis of a school- and community-based intervention to promote a healthy lifestyle and prevent type 2 diabetes in vulnerable families across Europe: The Feel4Diabetes-study.

Prev. Med. 153, DOI: 10.1016/j.ypmed.2021.106722 (2021)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The Feel4Diabetes-study implemented a school- and community-based intervention to promote healthy lifestyle and prevent type 2 diabetes mellitus (T2DM) in six European countries. The intervention included a special focus on families at increased T2DM risk. The current study evaluates the intervention's cost-effectiveness. A Markov-type health economic model was developed to predict the incidence of T2DM and its complications. Incremental cost-effectiveness ratios (lifetime horizon, societal perspective) were calculated based on the overall intervention effect on health behaviour, and stratified for low- and high-risk families. Sensitivity analyses captured input parameters uncertainty. A budget impact analysis was performed. The increase in children's water consumption and physical activity led to a modest gain in quality adjusted life years (QALYs) at a low intervention cost and budget impact. Medical cost savings due to avoided illness could only be achieved on the very long-term (>30 years). The intervention in its entirety was cost-effective (more QALYs at a reasonable investment) in Belgium, Finland, Bulgaria, and Hungary, while being dominant (net savings and more QALYs) in Greece and Spain. Results were cost-effective for the low-risk families, who only received the school- and community-based intervention component. Results for the high-risk families were only cost-effective (with considerable uncertainty) in Greece and Spain, but not when the intervention would need to be repeated. The Feel4Diabetes-intervention is potentially cost-effective, especially in countries with a high overweight and obesity prevalence, at a limited budget impact. The incremental financial investments to reach and support high-risk families did not result in the hoped-for health benefits.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Diabetes ; Health Economics ; High-risk Families ; Prevention; Economic-evaluation; Obesity; Overweight; Risk
ISSN (print) / ISBN 0091-7435
e-ISSN 0091-7435
Zeitschrift Preventive Medicine
Quellenangaben Band: 153 Heft: , Seiten: , Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 525 B St, Ste 1900, San Diego, Ca 92101-4495 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Pancreatic Beta Cell Research (IPI)
Förderungen European Union's Horizon 2020 research and innovation program