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Muley, C.* ; Bartelt, A.

Fuse your mitochondria, lose appetite: An anorexic, anti-obesity sphingolipid.

EMBO Mol. Med.:e14618 (2021)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Aberrant production of ceramides, the precursors of complex sphingolipids, is a hallmark of obesity and strongly linked to metabolic dysfunction (Meikle and Summers 2017). Ceramides are formed by recycling or de novo synthesis from sphingosine and a fatty acid side chain moiety. The side chain length determines lipotoxicity of ceramides, as those composed of C16:0 or C18:0 side chains are toxic whereas those with C24:0 or C24:1 are not (Meikle and Summers 2017). Counteracting the deleterious effects of high-fat diets (HFDs) rich in saturated fat either by inhibiting synthesis or by promoting degradation of ceramides mitigates insulin resistance and ectopic lipid accumulation (Meikle and Summers 2017). However, drugs that safely and selectively target ceramide metabolism have failed to translate into metabolic benefit in human trials so far.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Editorial
Schlagwörter Er Stress; Mff
ISSN (print) / ISBN 1757-4676
e-ISSN 1757-4684
Quellenangaben Band: , Heft: , Seiten: , Artikelnummer: e14618 Supplement: ,
Verlag Wiley
Verlagsort Chichester
Begutachtungsstatus Peer reviewed
Förderungen DFG