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Muley, C.* ; Bartelt, A.

Fuse your mitochondria, lose appetite: An anorexic, anti-obesity sphingolipid.

EMBO Mol. Med.:e14618 (2021)
Publ. Version/Full Text DOI
Open Access Gold
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Aberrant production of ceramides, the precursors of complex sphingolipids, is a hallmark of obesity and strongly linked to metabolic dysfunction (Meikle and Summers 2017). Ceramides are formed by recycling or de novo synthesis from sphingosine and a fatty acid side chain moiety. The side chain length determines lipotoxicity of ceramides, as those composed of C16:0 or C18:0 side chains are toxic whereas those with C24:0 or C24:1 are not (Meikle and Summers 2017). Counteracting the deleterious effects of high-fat diets (HFDs) rich in saturated fat either by inhibiting synthesis or by promoting degradation of ceramides mitigates insulin resistance and ectopic lipid accumulation (Meikle and Summers 2017). However, drugs that safely and selectively target ceramide metabolism have failed to translate into metabolic benefit in human trials so far.
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Publication type Article: Journal article
Document type Editorial
Keywords Er Stress; Mff
ISSN (print) / ISBN 1757-4676
e-ISSN 1757-4684
Quellenangaben Volume: , Issue: , Pages: , Article Number: e14618 Supplement: ,
Publisher Wiley
Publishing Place Chichester
Reviewing status Peer reviewed
Grants DFG