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Ehlich, H.* ; Cater, H.L.* ; Flenniken, A.M.* ; Goncalves Da Cruz, I.* ; Mura, A.M.* ; Ntafis, V.* ; Raess, M.* ; Selloum, M.* ; Stöger, C. ; Suchanova, S.* ; Vuolteenaho, R.* ; Brown, S.D.M.* ; Hérault, Y.* ; Hinttala, R.* ; Hrabě de Angelis, M. ; Kollias, G.* ; Kontoyiannis, D.L.* ; Malissen, B.* ; McKerlie, C.* ; Sedláček, R.* ; Wells, S.E.* ; Zarubica, A.* ; Rozman, J.* ; Sorg, T.*

INFRAFRONTIER quality principles in systemic phenotyping.

Mamm. Genome, DOI: 10.1007/s00335-021-09892-2 (2021)
Verlagsversion Forschungsdaten DOI
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Improving reproducibility and replicability in preclinical research is a widely discussed and pertinent topic, especially regarding ethical responsibility in animal research. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving, and distribution of model mammalian genomes, is addressing this issue by developing internal quality principles for its different service areas, that provides a quality framework for its operational activities. This article introduces the INFRAFRONTIER Quality Principles in Systemic Phenotyping of genetically altered mouse models. A total of 11 key principles are included, ranging from general requirements for compliance with guidelines on animal testing, to the need for well-trained personnel and more specific standards such as the exchange of reference lines. Recently established requirements such as the provision of FAIR (Findable, Accessible, Interoperable, Reusable) data are also addressed. For each quality principle, we have outlined the specific context, requirements, further recommendations, and key references.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Zeitschrift Mammalian Genome
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Begutachtungsstatus Peer reviewed
Förderungen European Union (European Regional Development Fund), under NSRF 20142020
European Union Research and Innovation programme Horizon 2020 (INFRAFRONTIER2020Grant)
InfrafrontierGR action
French state funds through the "Agence Nationale de la Recherche"
Czech Academy of Sciences
Ministry of Education, Youth and Sports of the Czech Republic
German Federal Ministry of Education and Research
UKRI Medical Research Council
Ontario Genomics with a Genomics Technology Platforms grant
Canadian Foundation for Innovation Major Sciences Initiatives
Biocenter Oulu
Biocenter Finland
Academy of Finland