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Chemotherapeutic effects on breast tumor hemodynamics revealed by eigenspectra multispectral optoacoustic tomography (eMSOT).

Theranostics 11, 7813-7828 (2021)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
Non-invasive monitoring of hemodynamic tumor responses to chemotherapy could provide unique insights into the development of therapeutic resistance and inform therapeutic decision-making in the clinic. Methods: Here, we examined the longitudinal and dynamic effects of the common chemotherapeutic drug Taxotere on breast tumor (KPL-4) blood volume and oxygen saturation using eigenspectra multispectral optoacoustic tomography (eMSOT) imaging over a period of 41 days. Tumor vascular function was assessed by dynamic oxygen-enhanced eMSOT (OE-eMSOT). The obtained in vivo optoacoustic data were thoroughly validated by ex vivo cryoimaging and immunohistochemical staining against markers of vascularity and hypoxia. Results: We provide the first preclinical evidence that prolonged treatment with Taxotere causes a significant drop in mean whole tumor oxygenation. Furthermore, application of OE-eMSOT showed a diminished vascular response in Taxotere-treated tumors and revealed the presence of static blood pools, indicating increased vascular permeability. Conclusion: Our work has important translational implications and supports the feasibility of eMSOT imaging for non-invasive assessment of tumor microenvironmental responses to chemotherapy.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Taxotere ; Breast Cancer ; Chemotherapy ; Docetaxel ; Optoacoustic ; Photoacoustic; Interstitial Fluid Pressure; Neoadjuvant Chemotherapy; Photoacoustic Tomography; Docetaxel Taxotere; Solid Tumors; Cancer; Paclitaxel; Hypoxia; Oxygenation; Resistance
e-ISSN 1838-7640
Journal Theranostics
Quellenangaben Volume: 11, Issue: 16, Pages: 7813-7828 Article Number: , Supplement: ,
Publisher Ivyspring
Publishing Place Po Box 4546, Lake Haven, Nsw 2263, Australia
Reviewing status Peer reviewed
Grants European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme
Deutsche Forschungsgemeinschaft (DFG)