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Maurer, J.* ; Hoene, M.* ; Weigert, C.

Signals from the circle: Tricarboxylic acid cycle intermediates as myometabokines.

Metabolites 11:474 (2021)
Publ. Version/Full Text DOI
Open Access Gold
Creative Commons Lizenzvertrag
Regular physical activity is an effective strategy to prevent and ameliorate aging-associ-ated diseases. In particular, training increases muscle performance and improves whole-body me-tabolism. Since exercise affects the whole organism, it has countless health benefits. The systemic effects of exercise can, in part, be explained by communication between the contracting skeletal muscle and other organs and cell types. While small proteins and peptides known as myokines are the most prominent candidates to mediate this tissue cross-talk, recent investigations have paid in-creasing attention to metabolites. The purpose of this review is to highlight the potential role of tricarboxylic acid (TCA) metabolites as humoral mediators of exercise adaptation processes. We focus on TCA metabolites that are released from human skeletal muscle in response to exercise and provide an overview of their potential auto-, para-or endocrine health-promoting effects.
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Publication type Article: Journal article
Document type Review
Keywords Arterio-venous Differ-ence ; Citrate ; Exercise ; Exercise Adaptation ; Liver ; Myometabokine ; Succinate ; Tca Cycle; Human Skeletal-muscle; Tca Cycle; Glyceraldehyde-3-phosphate Dehydrogenase; Chemical-modification; Lysine Succinylation; Malonyl-coa; Pool Size; Exercise; Metabolism; Succinate
ISSN (print) / ISBN 2218-1989
e-ISSN 2218-1989
Journal Metabolites
Quellenangaben Volume: 11, Issue: 8, Pages: , Article Number: 474 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Reviewing status Peer reviewed
Mobility Programme of the Sino-German Center for Research Promotion